INTRODUCTION xxxvii Charles V at Peschiera TTo the widespread fame of the poem Syphihis was due an incident that occurred eleven years after its publication, and is reckoned by the biographers who relate it as not the least of the laurels of Fracastorius. When Charles V, the most power— ful monarch in the world, was travelling from Germany through North Italy, on his way to Genoa to embark on his fruitless expedition against Algiers, he came to Peschiera in the summer of 1541. With the crowd of sightseers who had gathered to see the Emperor pass, stood Fracastorius, but a little apart, as was characteristic, and moreover he detested Charles V. It was very hot, and the Emperor rode without deigning to glance to the right or left, till Cardinal Madrucci who rode with him, pointed out Fracastorius. Charles halted, gazed at him earnest— ly, made a gesture to show that he recognized him, and rode on his way. 'This look? from the disdainful monarch was greatly exaggerated by the poet's descendants who, according to Manara, set up a tablet in the villa at Incaffi to commemorate a visit from Charles V. 'This would have outraged the feelings of Fracastorius, as may be judged by a poem which he wrote in 1552, not long before his death. Charles had been repulsed in May of that year, by an insignificant enemy, Maurice of Saxony, had had to flee! over the Brenner pass by night, and his fortune was evidently on the wane. Fracastorius addresses 23 Latin hexameters to this "terror of the world'', and pours out at last his hatred for the enemy of the Pope, the oppressor of Italy, over whom one might now safely exult. The Council of Trent In 1547 Fracastorius was involved in an affair in which all Europe, cleries and laymen alike, took a passionate interest, and which arose out of the intrigues of the Farnese Pope, Paul III, and the Emperor Charles V over the famous Counecil of Trent. "The Pope feared the results of any such Synod, unnecessarily are a compound of the inspired air with the most subtile portion of the blood . . . — of fiery potency, the lucid vapor of the blood?, and so on. Van Helmont, in the 17th cent. says there is a specifie ferment in the heart to generate vital spirits from the blood. :Vesalius may have fled with Charles, whose body—physician he became in 1546.