xxii INTRODUCTION three reasons. Its ravages were too widespread, and it broke out simultaneously in several countries; he eould eite many eases in the early period of persons who were afflicted sponta— neously, without any contaect whatever; finally, before its coming,, there was a conjunction of Mars, Jupiter and Saturn, & pheno— menon that regularly brings in its train inundations, earth— quakes and maladies.!' 'The original agent and seat of the distemper (principtum sedesque mali) must be the air, which easily suffers corruption and becomes charged with con/ages? novas. Two centuries earlier, the plagues which began in India and spread through Europe followed such a conjunection of the planets. Causes Was the contagion due to vapors^ from the earth, or were these engendered above? ^ This is hard to decide, for the nature of contagions is strange and varied. He instances, with more detail than in CorWZagion, specia!l pests that attack certain vegetables and animals, especially a distemper that attacked goats only. 'The semina of certain maladies rarely emerge, e. g. of elephantiasis, unknown in Italy. Such a contagion is this,5 which attacks only man.* The indications and symp— de la Isl&'s Tracfado, Wamado Fructo de todos los Sanctos, contra et mal serpeniino, venido de la Isla espanola, which, though of uncertain date, was written about 1506, and long antedated the first version of SyphiJs. See Haeser, Vol. III. p. 281. Nine years after the publication of Syphilis, when he was working on Conia— gion, Fracastorius wrote to Rannusio, Feb. 16th, 1539, asking for information about Hispaniola, what maladies exist there, especially such as are contagious, and whether they have guaiac. : These arguments are repeated in Contagion, p. 151. * On aecount of the metre, which often limits his terminology in this poem, he cannot write contagto, hence he uses confages; similarly, he cannot write seminaria, but only semina; or the plural of pustula, for which he gives achores. So Lucretius must use the purely poetical form pesfilitas, for pestilentia, which will not scan. sThe Black Death of 1348, immortalised in literature by the Decameron of Boccaccio, who says it was either due to the influence of the celestial bodies, or was a direct visitation of God to punish sin. 4I have not found the term 'miasma! in his medical works. 5 It is to be noted that he does not use the word 'syphilis' until Book III, after the tale of the shepherd from whose name the word is derived. 6 This is of course the modern view, but J. C. Scaliger, the friend